תיאור
תיאור המוצר
Genemed HER2 CISH Kit is intended to detect HER2 gene amplification in
formalin-fixed, paraffin-embedded (FFPE) tissue sections using Chromogenic In
Situ Hybridization.
The human gene HER2, or c-erbB-2, and the rat equivalent gene, neu, have
been identified as proto-oncogenes sharing homology with the closely related
v-erbB oncogene. The HER2 gene is located on chromosome 17 (17q12-21) and
encodes a 185 kDa membrane receptor-like protein. HER2 has tyrosine kinase
activity and shares homology with, but is distinct from, the epidermal growth factor
receptor (known as EGFr, HER1, or c-erbB-1).
Genemed HER2 Probe (Reagent C) is a double-stranded DNA probe that has
been labeled with digoxigenin. It is supplied in a liquid format in hybridization
buffer. It has been demonstrated to contain the HER2 gene by PCR, and to bind
specifically to the HER2 gene locus on chromosome 17q12-21 by metaphase
FISH in normal lymphocytes.
No. of Tests: 20 (20 μL probe per test) Catalog No.: 80-0001
Intended Use: USA RUO, CE IVD
